Landweber Lab

Location and Contact Information

Hammer Health Sciences Building
701 W. 168th St
Room: 712-723
New York, NY 10032
United States

Principal Investigators

A illustration of oxytricha.

Our lab studies novel genetic systems in microbial eukaryotes, bringing a strongly mechanistic approach to understanding genome evolution and diversity. Our research has shown that the surprisingly sophisticated variations on DNA and RNA processing in microbial eukaryotes create an imaginative playground for genome architecture and genetic systems. Some of their pathways erode the notions of a gene (e.g. scrambled genes and RNA editing) and even Mendelian inheritance, reminding us that a genome sequence can be a far cry from knowledge of its products. Genome-wide DNA rearrangements occur in diverse organisms, and contribute to many human diseases, including cancer, but their extreme exaggeration in ciliates, particularly Oxytricha, makes it an ideal model system to study the role of RNA in epigenetic control of genome remodeling. Our laboratory is currently focused on understanding the mechanism and evolutionary origin of this remarkable phenomenon in Oxytricha of RNA-guided, widespread genome editing during development.

Members

Publications

Research

Landweber Lab in the Media:

The Naked Scientists: The RNA world Hypothesis
Wired: This Bizarre Organism Builds Itself a New Genome Every Time It Has Sex
Science Daily: In One of Nature's Innovations, a Single Cell Smashes and Rebuilds its Own Genome